Basic Neurological Screening

The Behavioral Testing Core personnel can help with neurological screening of your mice and rats in a variety of paradigms.  Screening can identify behavioral phenotypes that may be interesting for further study or than might interfere with performance in different types of behavioral tasks.   These types of screens are also often used to test for drug effects.

Many of these screening tests can be performed in your lab with
our assistance prior to or without transfer to the Behavior Core.

Different screens can test a variety of phenotypes in the following categories:

     
General Behavior
Sensory Perception
Motor Control
Reflexes
Model Phenotypes
 

Penlight Vision Test

            The pupil dilation and contraction is assessed using a penlight in a dim environment.      

Hot Plate Test for Pain Sensitivity

      Subject is placed on a very warm surface and with a constantly controlled temperature.  The subject is tested for the latency to lift its hind paws.            

Tail Immersion Test

            Subject's tail is placed in very warm water with a constantly controlled temperature, and the latency to flick the tail is recorded.      

Grip Strength Assessment

      The forelimb and/or hindlimb grip strength of a subject is tested using a specially designed measurement apparatus.            

Gait Analysis

            Irregularities or unevenness of steps is measured for evidence of motor coordination or balance problems.      

Balance Beam

      Subjects' performance in crossing balance beams of varying degrees of difficulty is measured for evidence of motor coordination and balance.            

Forced Swim Test

            Since some mutations cause a deficit in swimming ability, the forced swim test can be used to demonstrate normal swimming and floating ability.
The test is most frequently used to examine the "learned helplessness" response common in animal models of depression.
     

Tail Suspension

      The subject is suspended by the tail for a set interval the percentage of time the subject spends still versus moving is examined for evidence of the "learned helplessness" response common in models of depression.            

Behavioral Tasks


Basic Neurological Screening

Vision Penlight
Hotplate
___________________________

Rat Services
Fear Conditioning
Startle/PPI
Morris Water Maze
Radial Arm Maze
T Maze
Social Interaction
Ultrasonic Vocalization
Novel Object Recognition
Conditioned Taste Aversion
Conditioned Place Preference
Aggression
Open Field
Roto-Rod
SHIRPA Primary Screen
Elevated Plus Maze
Light-Dark Box
Social Recognition
Social Transmission
    of Food Preference
Basic Neurological Screens
      ° Vision Penlight
      ° Hot Plate
      ° Tail Immersion
      ° Grip Strength
      ° Gait Analysis
      ° Balance Beam
      ° Forced Swim
      ° Tail Suspension

AND many more
available tests...

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